It will easier said than done for Boro as The Reds have won five of their last eight on home soil.
If they drop points and Runcorn Linnets fail to defeat second-bottom Kendal, Colls could potentially go seven points clear of second and third as they visit a Market Drayton side with just one win in their last eight at Greenfields Sports Ground.
With the race for the play-offs intensifying, the sides from fourth down to seventh could all realistically end the day in the top five.
Ramsbottom will put their nine-game winning run away from home on the line when they travel to 14th-placed Chasetown and Mossley head to Llanelian Road to go up against Colwyn Bay.
Elsewhere, Leek Town will look to end their four-game winless run as they take on in-form Prescot Cables. Brian Richardson’s side have lost just one of their last nine games, so victory for the Blues is certainly not assured.
Basement side Skelmersdale have lost eight of their last nine games on the road, but could a trip to Widnes, who have lost four of their last six at home, prove to be a catalyst for their great escape?
In the other games of the round, Droyslden have the chance to go within one point of 11th-placed Kidsgrove Athletic when they face off at the Butchers Arms Ground and Trafford host a Clitheroe side on a seven-game losing streak.
Meanwhile, Glossop North End will look to end their seven-game winless run on home soil against Newcastle Town.
Words by James Messenger